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About Mesothelioma
Learn about
Mesothelioma
Mesothelioma
is a rare type of cancer that develops in the pleura, the thin membrane that
separates the lungs from the chest wall. When it runs along the membrane, it
results in breathing difficulties, chest pain and fever. It usually occurs from
previous exposure to asbestos, a type of mineral fiber used in the insulation
industry. Less commonly, mesothelioma can also arise, more rarely, along the
lining of the stomach.
Key facts:
Mesothelioma
is a rare type of cancer that usually arises from the lining of the lungs
(pleura) & in the lining of the stomach (peritoneum).
Although
patients with mesothelioma have been exposed to asbestos, only a small
percentage of patients with exposure develop the disease.
Mesothelioma
is not caused because you smoke.
Other
causes have been identified, and sometimes it is unclear what causes a person
to get mesothelioma.
What Is
Mesothelioma?
There are
approximately 3,500 new cases of mesothelioma every year in the United States.
This is a very small number compared to lung cancer (220,000 new cases per year
in the United States). This is caused by exposure to asbestos in at least 80
percent of cases, and also in some cases, there may be exposure that may be
unknown to the patient. When asbestos fibers are inhaled into the lungs, they
can penetrate very deeply because of their small size and accumulate near the
lining of the lungs, or pleura. This fiber can irritate the pleura which
results in inflammation and growth of abnormal mesothelial cells (surface
layer), which can eventually cause cancer. Mesothelial cells that grow
abnormally produce tumor nodules on the lung surface and cause fluid
accumulation (pleural effusion) between the lungs and chest wall resulting in
pain and shortness of breath. There are other areas in the body with layers
that are similar to the pleura that can also be affected, although it is far
less frequent.
How
Mesothelioma Affects Parts of Your Body
Mesothelioma,
unlike cancer in general, tends to grow mainly along the surface of the lungs
& other chest surfaces resulting in pain due to nerve invasion, and
shortness of breath due to compression of the lungs or limitation of lung
expansion. Tumor nodules and fluid accumulate along the pleural space between
the lungs and chest wall. Sometimes tumor growth causes fever. Although
mesothelioma can spread to the chest lymph nodes and attack the lungs, it
rarely spreads throughout the body. If left untreated, mesothelioma worsens and
can cause death.
How Serious
is Mesothelioma?
Mesothelioma
is a very serious disease. While promising research efforts are underway, there
is currently no consistently more effective treatment for this disease.
However, symptomatic relief, sometimes called palliative or supportive care,
can often control debilitating symptoms. The severity of mesothelioma can vary
from person to person.
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Mesothelioma
Symptoms, Causes & Risk Factors
Mesothelioma
generally occurs in people who have previously been exposed to asbestos,
sometimes around 40 to 60 years before diagnosis. In most cases, mesothelioma
occurs at least 20 years after asbestos exposure. Those who get mesothelioma
are usually exposed to asbestos higher than those affected by other
asbestos-related diseases, including lung scarring (fibrosis) and lung cancer.
What are
the Symptoms of Mesothelioma?
Less than 5
percent of people exposed to asbestos will eventually develop mesothelioma.
Sometimes, the diagnosis found on chest X-rays is done for other reasons.
The most
common symptoms are:
- Hard to breathe
- Chest
pain, increases during breathing efforts
- Permanent
dry cough
- Frequent
cold symptoms of the chest
- The
development of cancer can also cause general symptoms such as:
- Weight
loss with low appetite
- general
fatigue
- Low grade
fever
When other
areas of the body are affected by mesothelioma, other local symptoms can occur:
When the
peritoneum or the lining of the stomach is involved, and swelling in the
abdomen, constipation, intestinal obstruction and pain and nausea can occur.
Abnormal
mass or swelling can be felt in the scrotum when the layer is involved
Rarely, the
body's defense mechanism can try to control the disease by at least producing
antibodies intended to fight cancer that can cause symptoms, such as
hypoglycemia, blood clots in the legs or lungs and various neurological
symptoms. These symptoms are called "paraneoplastic" which means
"related to cancer."
What Causes
Mesothelioma?
Researchers
are still trying to understand what causes mesothelioma, in addition to
responding to asbestos fibers over a long period of time.
What is
Asbestos?
When an
individual is exposed to asbestos, small fibers easily inhaled into the lungs,
increase the risk of developing mesothelioma, lung cancer or a type of
scar-lung disease called asbestosis.
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What is a Risk Factor?
Asbestos
Exposure: Asbestos is a mineral fiber that is fire resistant and also hot,
which has been used in insulation & refractory materials. Concerns about
human safety appeared at the beginning of the 20th and their use was eventually
banned or strictly regulated in most countries 30 years ago. Most individuals
who develop mesothelioma due to asbestos are exposed during their work, which
is called "occupational exposure". Typical jobs related to asbestos
exposure include mining or grinding, electricians, plumbers, plumbers,
insulators and even individuals who have renovated old homes or lived with
workers exposed to asbestos. Living at home that contains asbestos is generally
not considered a cause of mesothelioma when asbestos is closed on the walls and
ceiling, and is not directly inhaled by individuals.
Smoking is
not a risk factor for mesothelioma; However, quitting smoking is very
important: exposure to asbestos does not increase the risk of mesothelioma, but
increases the risk of lung cancer in general.
Other types
of fibers, such as erionite, are considered responsible for mesothelioma, too.
Erionite has been identified in certain regions of Turkey called Cappadocia and
is considered responsible for the high levels of mesothelioma observed in the
area.
Age: The
risk of developing mesothelioma increases with age. This is due to the fact
that it takes a long time for mesothelioma to develop after exposure to
asbestos, usually at least 20 years. This period of exposure to malignancy is
called latency.
Other
causes have been found, including radiation therapy before, especially in
patients who have received high-dose radiation therapy to the chest for cancer,
as in the treatment of lymphoma, and also certain rare genetic mutations. This
cause is far more common than asbestos exposure.
Stomach
& peritoneum
A piece of
tissue covering your stomach organs (stomach) is called the peritoneum. This
helps to protect your bowels and keeps them in place. It also creates a
lubricating liquid that helps the organs move smoothly towards each other as
you move.
Mesothelioma
of the tissue that lines your abdominal cavity is called peritoneal
mesothelioma. It usually does not spread to other body parts.
Benign
Mesothelioma
Very
rarely, this type of mesothelioma that is not cancerous (benign) can develop in
the lining of the lungs or the lining of your reproductive organs. This can
occur in men or women. This tumor is so rare that we don't cover it here.
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